About the compound
Acylated GLP-1(7-37) analog (C₁₈₇H₂₉₁N₄₅O₅₉, MW 4113.58 Da) with an Aib2 substitution and a γGlu-2×OEG-C18-diacid side chain at Lys20.
Semaglutide is a 31-residue GLP-1 receptor agonist (Class B GPCR ligand). The peptide backbone substitutes 2-aminoisobutyric acid (Aib) at position 2 to resist DPP-4 cleavage and substitutes Arg34Lys. Lys20 carries a side chain composed of γ-Glu followed by two OEG (8-amino-3,6-dioxaoctanoic acid) spacers and a C18 fatty diacid. Empirical formula C₁₈₇H₂₉₁N₄₅O₅₉; MW 4113.58 Da.
Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.
Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.
Selected primary literature.
- Lau J et al., 2015, J Med Chem 58(18):7370 — discovery and structural characterization of the lipidated GLP-1 analog semaglutide (preclinical structural study).
- Knudsen LB & Lau J, 2019, Front Endocrinol 10:155 — review of the structural design principles of long-acting GLP-1 receptor agonists.
What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.
For research use only. Not for human or animal consumption.
