Retatrutide

Retatrutide (LY3437943) is a 39-residue lipidated peptide that engages the GLP-1, GIP, and glucagon receptors. The sequence is published in WO/2021/254237; a γGlu-2×OEG-C20-diacid moiety is attached at Lys17.

Reconstitution. For in-vitro laboratory handling, dissolve with bacteriostatic water (0.9% benzyl alcohol). Compound is hygroscopic — handle in low-humidity conditions and re-cap immediately.

Stability profile. Lyophilized: stable at room temperature for up to 30 days sealed; long-term storage at -20 °C recommended. Reconstituted material: stable at 2–8 °C for up to 14 days.

Selected primary literature.
- Coskun T et al., 2022, Mol Metab 66:101618 — preclinical in-vitro tri-receptor binding and cAMP characterization of retatrutide.

What remains uncharacterized: concentration-response relationships in any specific in-vitro model system are not implied here. The literature cited above describes molecular-level observations only.

For research use only. Not for human or animal consumption.

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